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Therapeutic effects of icariin and icariside II on diabetes mellitus and its complications.

Authors :
Jiang, Wei
Ding, Kaixi
Yue, Rensong
Lei, Ming
Source :
Critical Reviews in Food Science & Nutrition. 2024, Vol. 64 Issue 17, p5852-5877. 26p.
Publication Year :
2024

Abstract

Diabetes mellitus (DM) is a global health issue in the twenty-first century, and there are numerous challenges in preventing and alleviating its chronic complications. The herb Epimedium has beneficial therapeutic effects on various human diseases, including DM. Its major flavonoid component, icariin, has significant anti-DM activity and may help improve pancreatic β-cell dysfunction and insulin resistance. Furthermore, preclinical evidence has shown that icariin and its in vivo bioactive form, icariside II, have preventive and therapeutic effects on several diabetic complications, including diabetic cardiomyopathy, diabetic vascular endothelial disorder, diabetic nephropathy, and diabetic erectile dysfunction. In this review, we present the general and toxicological information concerning icariin and icariside II and review the anti-DM effects of icariin from a molecular perspective. Additionally, we discuss the potential benefits of icariin and icariside II on the important pathological mechanisms of various diabetic complications. Despite positive preclinical evidence, additional investigations are needed before relevant clinical studies can be conducted. Therefore, we conclude with suggestions for future research. Hopefully, this review will provide a comprehensive molecular perspective for future research and product development related to icariin and icariside II in treating DM and diabetic complications. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
10408398
Volume :
64
Issue :
17
Database :
Academic Search Index
Journal :
Critical Reviews in Food Science & Nutrition
Publication Type :
Academic Journal
Accession number :
178088999
Full Text :
https://doi.org/10.1080/10408398.2022.2159317