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Characterization of the metabolic contributions of cytochrome P450 isoforms to bicyclol using the relative activity factor method.
- Source :
-
Journal of Asian Natural Products Research . Aug2024, Vol. 26 Issue 8, p918-929. 12p. - Publication Year :
- 2024
-
Abstract
- Bicyclol is a hepatoprotective agent widely used for treating chronic hepatitis and drug-induced liver injuries in clinics. The purpose of the study was to elucidate the contribution of CYP450 enzymes to the metabolism of bicyclol using the relative activity factor approach. After incubation with human liver microsomes and recombinant human liver CYP450 enzymes, the calculated contribution of CYP3A4 and 2C19 to the metabolism of bicyclol was 85.6–90.3% and 9.2–9.7%, respectively. The metabolism was interrupted in the presence of CYP3A4 and 2C19 selective inhibitors. These findings help to predict or avoid metabolic drug–drug interactions or toxicity in clinical applications of bicyclol. [ABSTRACT FROM AUTHOR]
- Subjects :
- *HEPATITIS prevention
*LIVER disease prevention
*RISK assessment
*IN vitro studies
*RESEARCH funding
*T-test (Statistics)
*LIQUID chromatography-mass spectrometry
*DYNAMICS
*DESCRIPTIVE statistics
*ISOENZYMES
*BIOTRANSFORMATION (Metabolism)
*CYTOCHROME P-450
*DRUG interactions
*MOLECULAR structure
*METABOLISM
*ORGANIC compounds
*DATA analysis software
*ANALYTICAL chemistry
*REGRESSION analysis
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 26
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 178088981
- Full Text :
- https://doi.org/10.1080/10286020.2024.2340072