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Simultaneous assessment of absorption and pharmacokinetic characteristics of four active flavonoids from Chimonanthus nitens Leaf Granules using LC-MS determination: in vivo and in vitro.
- Source :
-
Journal of Asian Natural Products Research . Aug2024, Vol. 26 Issue 8, p930-944. 15p. - Publication Year :
- 2024
-
Abstract
- A sensitive UPLC-HRMS method was developed and validated for simultaneous quantification of four active flavonoids from Chimonanthus nitens Leaf Granules (CNLG) in biological matrix. The method was utilized in pharmacokinetic study of the four flavonoids in rats as well as other evaluation assays in vitro. It was revealed that rutin, nicotiflorin, and astragalin had poor oral bioavailability in rats possibly due to low intestinal permeability and metabolism in intestinal flora. Kaempferol underwent rapid glucuronidation and sulphation in rat plasma with medium permeability coefficient. The results provided valuable data for future research and development of CNLG flavonoids. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CHINESE medicine
*IN vitro studies
*RUTIN
*ASTRAGALUS (Plants)
*LIQUID chromatography-mass spectrometry
*RESEARCH funding
*FLAVONOIDS
*INTESTINAL barrier function
*GUT microbiome
*IN vivo studies
*PLANT extracts
*RATS
*INTESTINAL absorption
*MOLECULAR structure
*ANIMAL experimentation
*LEAVES
*BIOAVAILABILITY
Subjects
Details
- Language :
- English
- ISSN :
- 10286020
- Volume :
- 26
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Journal of Asian Natural Products Research
- Publication Type :
- Academic Journal
- Accession number :
- 178088980
- Full Text :
- https://doi.org/10.1080/10286020.2024.2337807