Synthesis, structural studies and antimicrobial activity of copper(II) complexes derived from 2,4-difluoro-6-(((2-(pyrrolidin-1-yl)ethyl)imino)methyl)phenol.

Reaction of the Schiff base 2,4-difuloro-6-(((2-(pyrrolidin-1-yl)ethyl)imino)methyl)phenol (HL) with copper salts and some bridging ligands afforded five complexes, [CuClL] (1), [Cu(μ-Br)L] n (2), [Cu(μ-Br)(μ 1,5 -dca)L] n ·nCH 3 OH (3), [Cu(μ 1,3,5 -dca)L] n (4) and [Cu(μ 1,3 -N 3)L] n (5) (dca = dicyanoamide). These complexes have been analyzed and characterized by the means of elemental analysis, infrared and electronic spectra, as well as single crystal X-ray diffraction. The Cu atom in the mononuclear complex 1 is in square planar coordination, in the bromido-bridged polynuclear complex 2 is in square pyramidal coordination, in the bromido and dca co-bridged polynuclear complex 3 is in square pyramidal coordination, in the dca bridged polynuclear complex 4 is in octahedral coordination, and in the azido bridged polynuclear complex 5 is in square pyramidal coordination. The Schiff base ligand coordinates to the CuII ions through the phenolate oxygen, imine nitrogen and pyrrolidine nitrogen atoms. The biological study revealed that the complexes have good antimicrobial activity against the bacteria strains B. subtilis , S. aureus , E. coli and P. fluorescens. [Display omitted] Reaction of the Schiff base 2,4-difluoro-6-(((2-(pyrrolidin-1-yl)ethyl)imino)methyl)phenol (HL) with copper salts and some bridging ligands afforded five complexes, [CuClL] (1), [Cu(μ-Br)L] n (2), [Cu(μ-Br)(μ 1,5 -dca)L] n ·nCH 3 OH (3), [Cu(μ 1,3,5 -dca)L] n (4) and [Cu(μ 1,3 -N 3)L] n (5) (dca = dicyanoamide). These complexes have been analyzed and characterized by the means of elemental analysis, infrared and electronic spectra, as well as single crystal X-ray diffraction. The Cu atom in the mononuclear complex 1 is in square planar coordination, in the bromido-bridged polynuclear complex 2 is in square pyramidal coordination, in the bromido and dca co-bridged polynuclear complex 3 is in square pyramidal coordination, in the dca bridged polynuclear complex 4 is in octahedral coordination, and in the azido bridged polynuclear complex 5 is in square pyramidal coordination. The Schiff base ligand coordinates to the CuII ions through the phenolate oxygen, imine nitrogen and pyrrolidine nitrogen atoms. The biological study revealed that the complexes have good antimicrobial activity against the bacteria strains B. subtilis , S. aureus , E. coli and P. fluorescens. [ABSTRACT FROM AUTHOR]