Back to Search
Start Over
Association between the time of initial relapse and subsequent relapses in patients with childhood-onset idiopathic nephrotic syndrome.
- Source :
-
Pediatric Nephrology . Aug2024, Vol. 39 Issue 8, p2393-2401. 9p. - Publication Year :
- 2024
-
Abstract
- Background: Nephrotic syndrome relapse within 6 months is a known risk factor for steroid-dependent nephrotic syndrome/frequently relapsing nephrotic syndrome (SDNS/FRNS), but the risk of early development of SDNS/FRNS and initiation of immunosuppression therapy remains unknown. Methods: Patients with childhood-onset idiopathic nephrotic syndrome who had the first relapse within 6 months were enrolled. We analyzed the relationship between the time of the first relapse or the time of initial remission and incidence of SDNS/FRNS or initiation of immunosuppression therapy. Results: Forty-five patients were enrolled. Twenty out of 23 patients (87%) with the first relapse within 30 days after discontinuing initial steroid therapy experienced a second relapse within 30 days after discontinuing steroid therapy. Additionally, most patients in this group (96%) experienced a second relapse within 6 months after the onset and were diagnosed as SDNS/FRNS at this time. In this group, the incidence of SDNS/FRNS development within 6 months was 96%. In contrast, the incidence of SDNS/FRNS development within 6 months was 18% in patients with the first relapse more than 30 days after steroid discontinuation. The incidence of initiation of immunosuppressive agents within 6 months was 83% in the former group and 14% in the latter group. Conclusions: Most patients with the first relapse within 30 days after discontinuing steroid therapy developed SDNS/FRNS and were administered immunosuppressive agents within 6 months. Thus, it might be reasonable to start immunosuppression therapy in this group without waiting for the second relapse. [ABSTRACT FROM AUTHOR]
- Subjects :
- *STEROIDS
*RISK assessment
*IMMUNOSUPPRESSIVE agents
*SCIENTIFIC observation
*FISHER exact test
*RETROSPECTIVE studies
*DESCRIPTIVE statistics
*MANN Whitney U Test
*NEPHROTIC syndrome
*KAPLAN-Meier estimator
*LOG-rank test
*DISEASE relapse
*DATA analysis software
*DISEASE risk factors
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 0931041X
- Volume :
- 39
- Issue :
- 8
- Database :
- Academic Search Index
- Journal :
- Pediatric Nephrology
- Publication Type :
- Academic Journal
- Accession number :
- 178064737
- Full Text :
- https://doi.org/10.1007/s00467-024-06286-9