Analytical performance specifications – moving from models to practical recommendations.

This document discusses the concept of analytical performance specifications (APS) in laboratory medicine. It provides an overview of previous conferences and consensus documents on setting APS, including the 2014 EFLM Strategic Conference. The 2023 CELME conference aimed to explore the three models from the Milan conference and offer practical recommendations for their application. The document emphasizes the importance of APS in ensuring harmonized medical laboratory results for patient care. It also discusses the challenges in determining measurement uncertainty and the need for education on APS usage. The document concludes by highlighting important questions for further consideration, such as the creation of a single database for APS and the intended use and aspirational nature of APS. [Extracted from the article]