Establishment of a novel severe asthma canine model: Feasible research platform of respiratory intervention therapies.

This article discusses the establishment of a novel severe asthma canine model for research on respiratory intervention therapies. The researchers aimed to create a large animal model of asthma that closely mimics the clinical signs and features of severe asthma in humans. They exposed adult beagles to Toluene diisocyanate (TDI) via aerosol inhalation and observed pronounced asthma clinical signs, airway inflammation, and remodeling. The model also demonstrated the efficacy of respiratory intervention therapy. This model provides a valuable tool for studying the mechanisms and effectiveness of interventional pulmonological therapies for severe asthma. [Extracted from the article]