ATP 诱导细胞死亡与骨质疏松调控.

Osteoporosis, as a widespread skeletal system disease, its pathogenesis has not been fully elucidated. Studies have shown that there is a close relationship between ATP-induced cell death and osteoblasts, osteoclasts and bone marrow mesenchymal stem cells. ATP-induced cell death affects bone resorption, bone formation, and bone metabolism through multiple ways, involving the homeostasis of bone tissue and the pathogenesis of osteoporosis, and then participates in the pathological process of osteoporosis. In this paper, the molecular mechanism of ATP-induced cell death is reviewed, and the action mechanism of ATP in osteoporosis is deeply discussed, aiming to provide new research targets and diagnosis and treatment ideas for osteoporosis. [ABSTRACT FROM AUTHOR]