ONE-POT SYNTHESIS OF 5-(ARYL)-1,3,4-THIADIAZOLE-2-AMINES IN PEG-400.

A relatively green one-pot environmentally benign protocol has been developed for the smooth access of 5- (Substituted-phenyl)-[1,3,4]thiadiazole-2-amine derivatives. Present research involved the cyclocondensation response of substituted fragrant carboxylic acid and thiosemicarbazide under microwave irradiation with the usage of PEG-400 as a green catalyst. The protocol was found to be an easy, cheaper, and metallic-free green medium. The remarkable features of the present investigation are safe and environmentally benign, inexpensive, and use of nontoxic and non-volatile PEG-400 as a medium. The present study involved direct condensation of aromatic carboxylic acid with thiosemicarbazide in a minimum reaction time to obtain an excellent yield of thiadiazol-2-amines. [ABSTRACT FROM AUTHOR]