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Enhanced bioenergetic cellular activity with metabolic switch to aerobic glycolysis in Keloid and Folliculitis Keloidalis Nuchae.

Authors :
Chalwa, Temwani
Lebeko, Maribanyana
Matobole, Relebohile
P Khumalo, Nonhlanhla
Bayat, Ardeshir
Source :
Archives of Dermatological Research. Sep2024, Vol. 316 Issue 7, p1-13. 13p.
Publication Year :
2024

Abstract

Keloid scars and folliculitis keloidalis nuchae (FKN) are benign fibroproliferative dermal lesions of unknown aetiology and ill-defined treatment, which typically present in genetically susceptible individuals. Their pathognomonic hallmarks include local aggressive invasive behaviour plus high recurrence post-therapy. In view of this, we investigated proliferative and key parameters of bioenergetic cellular characteristics of site-specific keloid-derived fibroblasts (intra(centre)- and peri(margin)-lesional) and FKN compared to normal skin and normal flat non-hypertrophic scar fibroblasts as negative controls. The results showed statistically significant (P < 0.01) and variable growth dynamics with increased proliferation and migration in keloid fibroblasts, while FKN fibroblasts showed a significant (P < 0.001) increase in proliferation but similar migration profile to controls. A statistically significant metabolic switch towards aerobic glycolysis in the fibroblasts from the disease conditions was noted. Furthermore, an increase in basal glycolysis with a concomitant increase in the cellular maximum glycolytic capacity was also demonstrated in perilesional keloid and FKN fibroblasts (P < 0.05). Mitochondrial function parameters showed increased oxidative phosphorylation in the disease conditions (P < 0.05) indicating functional mitochondria. These findings further suggest that Keloids and FKN demonstrate a switch to a metabolic phenotype of aerobic glycolysis. Increased glycolytic flux inhibition is a potential mechanistic basis for future therapy. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
03403696
Volume :
316
Issue :
7
Database :
Academic Search Index
Journal :
Archives of Dermatological Research
Publication Type :
Academic Journal
Accession number :
177918601
Full Text :
https://doi.org/10.1007/s00403-024-03038-5