The effects of hyperbaric oxygen therapy on snake‐bite‐associated wounds in dogs.

Objective: To assess the effect of hyperbaric oxygen therapy (HBOT) on Crotalinae envenomation‐induced wound swelling and severity and pain in dogs, and to describe the safety and complications of HBOT. Design: Prospective, randomized, controlled, blinded study (2017–2021). Setting: University teaching hospital, private veterinary practice. Animals: Thirty‐six client‐owned dogs presenting within 24 hours of a confirmed or suspected naturally occurring Crotalinae snake bite injury were enrolled between 2017 and 2021. Interventions: In addition to the standard of care treatment, dogs received 2 interventions with either HBOT (n = 19) or control (n = 16) within 24 hours of hospital admission. Dogs receiving HBOT were pressurized over 15 minutes (1 psi/min), maintained at a target pressure of 2 atmosphere absolute (ATA) for 30 minutes, and decompressed over 15 minutes. Control dogs received 1 ATA for 1 hour. Local wound swelling, wound severity score, and pain score were assessed at admission, before and after each intervention, and at hospital discharge. Measurements and Main Results: There was no significant difference in wound swelling (P = 0.414), severity score (P = 1.000), or pain score (P = 0.689) between HBOT and control groups. Pain decreased significantly over time regardless of the study intervention (P < 0.001). There were no major adverse effects associated with either study intervention. Conclusions: HBOT did not significantly alter the short‐term recovery from Crotalinae envenomation in this study population. However, the study might be underpowered to detect a significant treatment effect. [ABSTRACT FROM AUTHOR]