LncRNA taurine upregulated gene 1 in liver disease.

• This study perhaps reveals the potential role of LncRNA TUG1 in liver diseases. • Numerous studies have demonstrated the potential efficacy of drugs targeting LncRNA TUG1 in the treatment of liver diseases. • LncRNA TUG1 may serve as a prognostic marker in liver diseases. • LncRNA TUG1 may regulate microRNA and downstream target proteins in liver diseases. Long non-coding RNAs (lncRNAs) are RNA sequences exceeding 200 nucleotides in length that lack protein-coding capacity and participate in diverse biological processes in the human body, particularly exerting a pivotal role in disease surveillance, diagnosis, and progression. Taurine upregulated gene 1 (TUG1) is a versatile lncRNA, and recent studies have revealed that the aberrant expression or function of TUG1 is intricately linked to the pathogenesis of liver diseases. Consequently, we have summarized the current understanding of the mechanism of TUG1 in liver diseases such as liver fibrosis, fatty liver, cirrhosis, liver injury, hepatitis, and liver cancer. Moreover, mounting evidence suggests that interventions targeting TUG1 or its downstream pathways may hold therapeutic promise for liver diseases. This review elucidates the characteristics, mechanisms, and targets of TUG1 in liver diseases, offering a theoretical basis for the prevention, diagnosis, treatment, and prognostic biomarkers of liver diseases. [ABSTRACT FROM AUTHOR]