Amygdala enlargement in temporal lobe epilepsy: Histopathology and surgical outcomes.

Objectives: Amygdala enlargement is detected on magnetic resonance imaging (MRI) in some patients with drug‐resistant temporal lobe epilepsy (TLE), but its clinical significance remains uncertain We aimed to assess if the presence of amygdala enlargement (1) predicted seizure outcome following anterior temporal lobectomy with amygdalohippocampectomy (ATL‐AH) and (2) was associated with specific histopathological changes. Methods: This was a case–control study. We included patients with drug‐resistant TLE who underwent ATL‐AH with and without amygdala enlargement detected on pre‐operative MRI. Amygdala volumetry was done using FreeSurfer for patients who had high‐resolution T1‐weighted images. Mann–Whitney U test was used to compare pre‐operative clinical characteristics between the two groups. The amygdala volume on the epileptogenic side was compared to the amygdala volume on the contralateral side among cases and controls. Then, we used a two‐sample, independent t test to compare the means of amygdala volume differences between cases and controls. The chi‐square test was used to assess the correlation of amygdala enlargement with (1) post‐surgical seizure outcomes and (2) histopathological changes. Results: Nineteen patients with and 19 patients without amygdala enlargement were studied. Their median age at surgery was 38 years for cases and 39 years for controls, and 52.6% were male. There were no statistically significant differences between the two groups in their pre‐operative clinical characteristics. There were significant differences in the means of volume difference between cases and controls (Diff = 457.2 mm3, 95% confidence interval [CI] 289.6–624.8; p <.001) and in the means of percentage difference (p <.001). However, there was no significant association between amygdala enlargement and surgical outcome (p =.72) or histopathological changes (p =.63). Significance: The presence of amygdala enlargement on the pre‐operative brain MRI in patients with TLE does not affect the surgical outcome following ATL‐AH, and it does not necessarily suggest abnormal histopathology. These findings suggest that amygdala enlargement might reflect a secondary reactive process to seizures in the epileptogenic temporal lobe. [ABSTRACT FROM AUTHOR]