N-Methylpyridinium Methyl Sulfate: An Exceptional Reaction Medium for the Room Temperature Synthesis of Substituted Pyrimidinones via Biginelli Reaction.

The syntheses of pyrimidinone derivatives by the Biginelli reaction in N-methylpyridinium methyl sulfate [mPyrMeSO4] as an ionic liquid medium have been reported. This protocol provides a highly efficient and selective route for the synthesis of structurally diverse pyrimidinones under milder reaction conditions. The proposed conditions tolerate differently substituted aldehydes and ketones and afford products in synthetically useful yields. Furthermore, camphor, benzil, benzoin, and ethyl acetoacetate were utilized for the Biginelli reaction for the first time, and the resulting pyrimidinones were obtained in excellent yields. [ABSTRACT FROM AUTHOR]