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The roles of B cells in cardiovascular diseases.
- Source :
-
Molecular Immunology . Jul2024, Vol. 171, p36-46. 11p. - Publication Year :
- 2024
-
Abstract
- Damage to the heart can start the repair process and cause cardiac remodeling. B cells play an important role in this process. B cells are recruited to the injured place and activate cardiac remodeling through secreting antibodies and cytokines. Different types of B cells showed specific functions in the heart. Among all types of B cells, heart-associated B cells play a vital role in the heart by secreting TGFβ1. B cells participate in the activation of fibroblasts and promote cardiac fibrosis. Four subtypes of B cells in the heart revealed the relationship between the B cells' heterogeneity and cardiac remodeling. Many cardiovascular diseases like atherosclerosis, heart failure (HF), hypertension, myocardial infarction (MI), and dilated cardiomyopathy (DCM) are related to B cells. The primary mechanisms of these B cell-related activities will be discussed in this review, which may also suggest potential novel therapeutic targets. • We summarized the relationship between B cells and cardiac remodeling. • In different cardiovascular diseases, B cells express different biomarkers and play different roles in cardiac fibrosis. • According to the mechanism of B cell action, potential therapeutic targets were proposed. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 01615890
- Volume :
- 171
- Database :
- Academic Search Index
- Journal :
- Molecular Immunology
- Publication Type :
- Academic Journal
- Accession number :
- 177757371
- Full Text :
- https://doi.org/10.1016/j.molimm.2024.05.002