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Production of therapeutic glycoproteins in glycoengineered plant: old farm for new crops.
- Source :
-
Current Opinion in Biotechnology . Jun2024, Vol. 87, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- Plant-based expression systems have emerged as promising avenues for the production of recombinant N -linked glycoproteins. This review offers insights into the evolution and progress of plant glycoengineering. It delves into the distinctive features of plant-derived N -glycans, the diverse range of plant hosts employed for glycoprotein synthesis, and the advancements in glycoengineering strategies aimed at generating glycoproteins with N -glycan structures akin to those produced in mammalian cell lines. Furthermore, alternative strategies for augmenting glycoengineering efforts and the current spectrum of applications for plant-produced N -glycan recombinant proteins are examined, underscoring their potential significance in biopharmaceutical manufacturing. • Plant-based expression systems are promising for producing recombinant N -linked glycoproteins. • Review explores plant glycoengineering history and recent advances in innovative vectors. • Hosts like Nicotiana benthamiana, Nicotiana tabacum BY-2 cells, are investigated. • Significant progress in optimizing glycoengineering strategies for mammalian-like glycosylation. • Review highlights biopharmaceutical manufacturing using glycoengineered plants. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 09581669
- Volume :
- 87
- Database :
- Academic Search Index
- Journal :
- Current Opinion in Biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 177752799
- Full Text :
- https://doi.org/10.1016/j.copbio.2024.103145