Exploring the solubility and intermolecular interactions of biologically significant amino acids l-serine and L-cysteine in binary mixtures of H2O + DMF, H2O + DMSO and H2O + ACN in temperature range from T = 288.15 K to 308.15 K

In the presented work, a study on the solubility and intermolecular interactions of l -serine and L-cysteine was carried out in binary mixtures of H 2 O + dimethylformamide (DMF), H 2 O + dimethylsulfoxide (DMSO), and H 2 O + acetonitrile (ACN) in the temperature range of T = 288.15 K to 308.15 K. l -serine exhibited the highest solubility in water, while L-cysteine was more soluble in water-DMF. The solvation process was assessed through standard Gibbs energy calculations, indicating the solvation stability order: water-ACN > water-DMSO > water-DMF for l -serine, and water-DMF > water-DMSO > water-ACN for L-cysteine. This study also explored the influence of these amino acids on solvent–solvent interactions, revealing changes in chemical entropies and self-association patterns within the binary solvent mixtures. Variation of solubility of L-cysteine in Water-DMF in various mole fraction concentrations of DMF (X DMF) with temperature (K). [Display omitted] • l-serine shows highest solubility in water, generally decreasing with organic components, except water-ACN solvent system. • L-cysteine is more soluble in water-DMF, solubility order: water-DMF > water-DMSO > water-ACN. • Standard Gibbs energy calculations reveal l -serine's stability: most in water-DMSO, least in water-ACN. • Non-covalent interactions govern stability, l -serine's solvation most affected by DMF, while L-cysteine by ACN. [ABSTRACT FROM AUTHOR]