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Cytotoxic Diterpenoid Alkaloids from Aconitum austroyunnanense.
- Source :
-
Chemistry of Natural Compounds . May2024, Vol. 60 Issue 3, p472-475. 4p. - Publication Year :
- 2024
-
Abstract
- A phytochemical investigation on the roots of Aconitum austroyunnanense led to the isolation of two previously undescribed diterpenoid alkaloids, austroyunnanines D and E (1 and 2). Their structures were determined by spectral methods such as 1D and 2D (1H–1H COSY, HMQC, NOESY, and HMBC) NMR spectroscopy, in addition to high-resolution mass spectrometry. The isolated compounds were tested in vitro for cytotoxic activity against three human gastric carcinoma cell lines. As a result, compound 1 exhibited some cytotoxicities against all the tested tumor cell lines with IC50 values less than 20.0 μM. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00093130
- Volume :
- 60
- Issue :
- 3
- Database :
- Academic Search Index
- Journal :
- Chemistry of Natural Compounds
- Publication Type :
- Academic Journal
- Accession number :
- 177741305
- Full Text :
- https://doi.org/10.1007/s10600-024-04354-y