Back to Search
Start Over
Impact of Tumor Shrinkage Pattern with Biweekly Triplet Gemcitabine+Cisplatin+S-1 Regimen for Biliary Tract Cancers: Implications for Neoadjuvant Therapy from the Data of KHBO1401 (KHBO1401-1A Study).
- Source :
-
Oncology . 2024, Vol. 102 Issue 6, p447-456. 10p. - Publication Year :
- 2024
-
Abstract
- Introduction: The multicenter randomized phase III KHBO1401 study (gemcitabine+cisplatin+S-1 [GCS] vs. GC in biliary tract cancers [BTC]) demonstrated that GCS not only prolonged patient survival but also achieved a high response rate and that it should be good for neoadjuvant therapy. Therefore, to explore the possibilities of neoadjuvant therapy, we investigated the tumor shrinkage pattern. Methods: Among the total of 246 patients enrolled in the KHBO1401, the tumor shrinkage pattern and survival were investigated in patients with measurable BTC (n = 183, 74%; GCS, n = 91; GC, n = 92). Results: The tumor shrinkage pattern could be divided into 4 categories based on the response at 100 days after enrollment: categories A (<–30% in size), B (−30–0%), C (0% to +20%), and D (>+20%). The GCS arm included more category A and B cases (61 [67%] vs. 33 [36%], p < 0.0001). Each category predicted the best response and overall survival (p < 0.0001). Category A showed sustained tumor response compared with category B; in GCS, the time to maximum tumor response was 165 ± 76 days in category A and 139 ± 78 in category B. Categories C and D did not achieve tumor shrinkage. The maximum tumor shrinkage size in category A was −53% in the GCS arm and −65% in the GC arm (p = 0.0892). Twenty percent of patients in the GCS showed tumor regrowth 154 ± 143 days later. Conclusion: GCS provided faster and greater tumor shrinkage with better survival in comparison to GC, although 20% of patients showed regrowth after 6 cycles. [ABSTRACT FROM AUTHOR]
- Subjects :
- *THERAPEUTIC use of antineoplastic agents
*CISPLATIN
*PREDICTION models
*CANCER relapse
*RESEARCH funding
*TUMOR markers
*DESCRIPTIVE statistics
*GLASGOW Coma Scale
*RELATIVE medical risk
*CHI-squared test
*CANCER chemotherapy
*KAPLAN-Meier estimator
*GEMCITABINE
*COMBINED modality therapy
*SURVIVAL analysis (Biometry)
*COMPARATIVE studies
*CONFIDENCE intervals
*DATA analysis software
*OVERALL survival
BILE duct tumors
Subjects
Details
- Language :
- English
- ISSN :
- 00302414
- Volume :
- 102
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- Oncology
- Publication Type :
- Academic Journal
- Accession number :
- 177720157
- Full Text :
- https://doi.org/10.1159/000533669