Navigating an enigma: the continuing journey of autoimmunity discoveries.

The article offers information on the advances in understanding autoimmune diseases (ADs). Topics include the identification and role of autoantibodies in diagnosing and understanding diseases like systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA), the contribution of genetic and epigenetic factors to AD predisposition and severity, and the influence of environmental stimuli and cell death pathways on the generation and persistence of autoantigens leading to autoimmune responses.