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Intestinal Bacteria Fluctuating in Early-Stage Colorectal Cancer Carcinogenesis are Associated with Diet in Healthy Adults.

Authors :
Narii, Nobuhiro
Zha, Ling
Sobue, Tomotaka
Kitamura, Tetsuhisa
Komatsu, Masayo
Shimomura, Yoshimitsu
Shiba, Satoshi
Mizutani, Sayaka
Yamada, Takuji
Yachida, Shinichi
Source :
Nutrition & Cancer. 2024, Vol. 76 Issue 6, p521-528. 8p.
Publication Year :
2024

Abstract

This hospital-based, cross-sectional study aimed to explore the association between diet and fluctuating intestinal bacteria in early-stage colorectal cancer (CRC) (Atopobium parvulum, Actinomyces odontolyticus, Solobacterium moorei, and Bifidobacterium longum). Healthy participants (n = 212) who underwent total colonoscopy at National Cancer Center Hospital (Tokyo, Japan) were divided into two groups according to the relative abundance of bacteria in their feces: those in the top 25% of relative bacterial abundance as cases and the bottom 25% as controls. The participants were divided into three groups (low, medium, and high) according to their intake of food groups associated with CRC. Multivariable logistic regression analysis was conducted to estimate the association between dietary intake and higher relative abundance of bacteria. Dairy products were inversely associated with a higher relative abundance of A. parvulum, A. odontolyticus, and S. moorei, with odds ratios (high vs. low) and 95% confidence interval as follows: 0.16 (0.06–0.44), 0.25 (0.08–0.82), and 0.29 (0.11–0.78), respectively. Additionally, dietary fiber was inversely associated with a higher relative abundance of S.moorei (0.29 [0.11–0.78]). No association was observed between diet and B.longum. In conclusion, healthy adults with a higher intake of dairy products and fiber had lower odds of having a higher relative abundance of CRC-associated microbiota. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
01635581
Volume :
76
Issue :
6
Database :
Academic Search Index
Journal :
Nutrition & Cancer
Publication Type :
Academic Journal
Accession number :
177672820
Full Text :
https://doi.org/10.1080/01635581.2024.2344257