Predicting functional impairments with lesion‐derived disconnectome mapping: Validation in stroke patients with motor deficits.

Focal structural damage to white matter tracts can result in functional deficits in stroke patients. Traditional voxel‐based lesion‐symptom mapping is commonly used to localize brain structures linked to neurological deficits. Emerging evidence suggests that the impact of structural focal damage may extend beyond immediate lesion sites. In this study, we present a disconnectome mapping approach based on support vector regression (SVR) to identify brain structures and white matter pathways associated with functional deficits in stroke patients. For clinical validation, we utilized imaging data from 340 stroke patients exhibiting motor deficits. A disconnectome map was initially derived from lesions for each patient. Bootstrap sampling was then employed to balance the sample size between a minority group of patients exhibiting right or left motor deficits and those without deficits. Subsequently, SVR analysis was used to identify voxels associated with motor deficits (p <.005). Our disconnectome‐based analysis significantly outperformed alternative lesion‐symptom approaches in identifying major white matter pathways within the corticospinal tracts associated with upper–lower limb motor deficits. Bootstrapping significantly increased the sensitivity (80%–87%) for identifying patients with motor deficits, with a minimum lesion size of 32 and 235 mm3 for the right and left motor deficit, respectively. Overall, the lesion‐based methods achieved lower sensitivities compared with those based on disconnection maps. The primary contribution of our approach lies in introducing a bootstrapped disconnectome‐based mapping approach to identify lesion‐derived white matter disconnections associated with functional deficits, particularly efficient in handling imbalanced data. [ABSTRACT FROM AUTHOR]