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Ceftazidim/avibaktam u liječenju intrahospitalnih pneumonija kod mehanički ventiliranih bolesnika s infekcijom COVID-19.

Authors :
Mandarić, Anja
Šitum, Ivan
Siroglavić, Marko
Lovrić, Daniel
Karmelić, Dora
Erceg, Ante
Mažar, Mirabel
Mihaljević, Slobodan
Source :
Medicina Fluminensis. 2024, Vol. 60 Issue 2, p153-163. 11p.
Publication Year :


In the period of the coronavirus diseFase 2019 (COVID-19) pandemic, many patients requiring invasive mechanical ventilation were admitted to the intensive care unit (ICU) due to severe respiratory failure associated with COVID-19 infection. In fact, ICU admission and invasive ventilation increased the risk of ventilator-associated pneumonia (VAP), which is associated with a high mortality rate and longer ICU and hospital stays. Pseudomonas aeruginosa was the first causative agent of this pathology (VAP), but rare non-fermenting Gram-negative microorganisms such as Burkholderia cepacea and Stenotrophomonas maltophilia have also emerged as potential etiological agents. One of the most frequently used antibiotics against carbapenem- resistant Gram-negative microorganisms is ceftazidime/avibactam (CZA). The aim of this review article was to describe the use of CZA in a series of cases of patients with COVID-19 infection who developed difficult-to-treat VAP due to P. aeruginosa, B. cepacea and S. maltophilia and to compare it with data published in the literature, as well as to draw attention to the continuous administration of the drug as a different modality compared to the standard method of bolus administration. Despite the high mortality of critically ill patients with COVID-19, CZA, especially in combination therapy, could represent a valid treatment option for VAP caused by non-fermenting Gram-negative microorganisms. [ABSTRACT FROM AUTHOR]


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Academic Search Index
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Medicina Fluminensis
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Academic Journal
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