Back to Search
Start Over
Nuclear Factor Erythroid 2-Related Factor 2 as a Potential Therapeutic Target in Neonatal Hypoxic-Ischemic Encephalopathy.
- Source :
-
Journal of Integrative Neuroscience . 2024, Vol. 23 Issue 5, p1-12. 12p. - Publication Year :
- 2024
-
Abstract
- Hypoxic-ischemic encephalopathy (HIE) is a prominent cause of neonatal mortality and neurodevelopmental disorders; however, effective therapeutic interventions remain limited. During neonatal hypoxic-ischemic injury events, increased reactive oxygen species (ROS) production and decreased antioxidant levels lead to the induction of oxidative stress, which plays a pivotal role in the pathological process of neonatal HIE. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key endogenous antioxidant transcription factor that protects against oxidative stress by promoting the transcription of various antioxidant genes. It has been demonstrated that Nrf2 signaling pathway activation by different compounds may protect against neonatal HIE. This review outlines the role of oxidative stress in neonatal HIE and summarizes the impact of antioxidants on neonatal HIE via activation of the Nrf2 signaling pathway. In conclusion, Nrf2 signaling pathway potentially exerts antioxidant, anti-inflammatory, antiapoptotic and antiferroptotic effects, thereby emerging as a focal point for future neonatal HIE treatment strategies. [ABSTRACT FROM AUTHOR]
- Subjects :
- *NUCLEAR factor E2 related factor
*CEREBRAL anoxia-ischemia
*TRANSCRIPTION factors
Subjects
Details
- Language :
- English
- ISSN :
- 02196352
- Volume :
- 23
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Journal of Integrative Neuroscience
- Publication Type :
- Academic Journal
- Accession number :
- 177615028
- Full Text :
- https://doi.org/10.31083/j.jin2305103