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Regulation of N6‐methyladenosine modification in erythropoiesis and thalassemia.

Regulation of N6‐methyladenosine modification in erythropoiesis and thalassemia.

Authors :
Zheng, Yanping
Lin, Siyang
Chen, Meihuan
Xu, Liangpu
Huang, Hailong
Source :
Clinical Genetics. Jul2024, Vol. 106 Issue 1, p3-12. 10p.
Publication Year :
2024

Abstract

In eukaryotic RNA, N6‐methyladenosine (m6A) is a prevalent form of methylation modification. The m6A modification process is reversible and dynamic, written by m6A methyltransferase complex, erased by m6A demethylase, and recognized by m6A binding proteins. Through mediating RNA stability, decay, alternative splicing, and translation processes, m6A modification regulates gene expression at the post‐transcriptional level. Erythropoiesis is the process of hematopoietic stem cells undergoing proliferation, a series of differentiation and maturation to form red blood cells (RBCs). Thalassemia is a common monogenic disease characterized by excessive production of ineffective RBCs in the peripheral circulation, resulting in hemolytic anemia. Increasing evidence suggests that m6A modification plays a crucial role in erythropoiesis. In this review, we comprehensively summarize the function of m6A modification in erythropoiesis and further generalize the mechanism of m6A modification regulating ineffective erythropoiesis and fetal hemoglobin expression. The purpose is to improve the understanding of the pathogenesis of erythroid dysplasia and offer new perspectives for the diagnosis and treatment of thalassemia. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
00099163
Volume :
106
Issue :
1
Database :
Academic Search Index
Journal :
Clinical Genetics
Publication Type :
Academic Journal
Accession number :
177613315
Full Text :
https://doi.org/10.1111/cge.14518