Back to Search Start Over

Immediate drop of urine osmolality upon tolvaptan initiation predicts impact on renal prognosis in patients with ADPKD.

Immediate drop of urine osmolality upon tolvaptan initiation predicts impact on renal prognosis in patients with ADPKD.

Authors :
Akihisa, Taro
Kataoka, Hiroshi
Makabe, Shiho
Manabe, Shun
Yoshida, Rie
Ushio, Yusuke
Sato, Masayo
Yajima, Aiji
Hanafusa, Norio
Tsuchiya, Ken
Nitta, Kosaku
Hoshino, Junichi
Mochizuki, Toshio
Source :
Nephrology Dialysis Transplantation. Jun2024, Vol. 39 Issue 6, p1008-1015. 8p.
Publication Year :
2024

Abstract

Background Tolvaptan, a vasopressin V2 receptor antagonist, is used for treating autosomal dominant polycystic kidney disease (ADPKD). We focused on changes in urinary osmolality (U-Osm) after tolvaptan initiation to determine whether they were associated with the therapeutic response to tolvaptan. Methods This was a single-centre, prospective, observational cohort study. Seventy-two patients with ADPKD who received tolvaptan were recruited. We analysed the relationship between changes in U-Osm and annual estimated glomerular filtration rate (eGFR) in terms of renal prognostic value using univariable and multivariable linear regression analyses. Results The mean value of U-Osm immediately before tolvaptan initiation was 351.8 ± 142.2 mOsm/kg H2O, which decreased to 97.6 ± 23.8 mOsm/kg H2O in the evening. The decrease in U-Osm was maintained in the outpatient clinic 1 month later. However, the 1-month values of U-Osm showed higher variability (160.2 ± 83.8 mOsm/kg H2O) than did those in the first evening of tolvaptan administration. Multivariate analysis revealed that the baseline eGFR, baseline urinary protein and U-Osm change in the evening of the day of admission (initial U-Osm drop) were significantly correlated with the subsequent annual change in eGFR. Conclusions U-Osm can be measured easily and rapidly, and U-Osm change within a short time after tolvaptan initiation may be a useful index for the renal prognosis in actual clinical practice. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09310509
Volume :
39
Issue :
6
Database :
Academic Search Index
Journal :
Nephrology Dialysis Transplantation
Publication Type :
Academic Journal
Accession number :
177577639
Full Text :
https://doi.org/10.1093/ndt/gfad232