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From bile acids to melancholia.
- Source :
-
Neuron . Jun2024, Vol. 112 Issue 11, p1725-1727. 3p. - Publication Year :
- 2024
-
Abstract
- In this issue of Neuron , Li, Zhang, et al. 1 find that the bile acid receptor TGR5 in the lateral hypothalamus influences neuronal dynamics underlying stress-induced depression-like behaviors. Inhibition of these neurons produces antidepressant-like effects through a circuit that includes hippocampal CA3 and dorsolateral septum, revealing a novel potential therapeutic for depression. In this issue of Neuron , Li, Zhang, et al. find that the bile acid receptor TGR5 in the lateral hypothalamus influences neuronal dynamics underlying stress-induced depression-like behaviors. Inhibition of these neurons produces antidepressant-like effects through a circuit that includes hippocampal CA3 and dorsolateral septum, revealing a novel potential therapeutic for depression. [ABSTRACT FROM AUTHOR]
- Subjects :
- *BILE acids
*FARNESOID X receptor
*HYPOTHALAMUS
Subjects
Details
- Language :
- English
- ISSN :
- 08966273
- Volume :
- 112
- Issue :
- 11
- Database :
- Academic Search Index
- Journal :
- Neuron
- Publication Type :
- Academic Journal
- Accession number :
- 177566862
- Full Text :
- https://doi.org/10.1016/j.neuron.2024.05.007