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Predicting the Rapid Progression of Mild Cognitive Impairment by Intestinal Flora and Blood Indicators through Machine Learning Method.
- Source :
-
Neurodegenerative Diseases . 2023, Vol. 23 Issue 3/4, p43-52. 10p. - Publication Year :
- 2023
-
Abstract
- Introduction: The aim of the work was to establish a prediction model of mild cognitive impairment (MCI) progression based on intestinal flora by machine learning method. Method: A total of 1,013 patients were recruited, in which 87 patients with MCI finished a two-year follow-up. To establish a prediction model, 61 patients were randomly divided into a training set and 26 patients were divided into a testing set. A total of 121 features including demographic characteristics, hematological indicators, and intestinal flora abundance were analyzed. Results: Of the 87 patients who finished a two-year follow-up, 44 presented rapid progression. Model 1 was established based on 121 features with the accuracy 85%, sensitivity 85%, and specificity 83%. Model 2 was based on the first fifteen features of model 1 (triglyceride, uric acid, alanine transaminase, F-Clostridiaceae, G-Megamonas, S-Megamonas, G-Shigella, G-Shigella, S-Shigella, average hemoglobin concentration, G-Alistipes, S-Collinsella, median cell count, average hemoglobin volume, low-density lipoprotein), with the accuracy 97%, sensitivity 92%, and specificity 100%. Model 3 was based on the first ten features of model 1, with the accuracy 97%, sensitivity 86%, and specificity 100%. Other models based on the demographic characteristics, hematological indicators, or intestinal flora abundance features presented lower sensitivity and specificity. Conclusion: The 15 features (including intestinal flora abundance) could establish an effective model for predicting rapid MCI progression. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 16602854
- Volume :
- 23
- Issue :
- 3/4
- Database :
- Academic Search Index
- Journal :
- Neurodegenerative Diseases
- Publication Type :
- Academic Journal
- Accession number :
- 177558757
- Full Text :
- https://doi.org/10.1159/000538023