Quinolinamide-Enabled Nickel-Catalyzed Regio- and Diastereoselective γ,δ-Arylalkylation of Nonactivated Alkenes.

This article explores the challenges and strategies involved in selectively adding carbon-based units to nonactivated alkenes. The authors focus on the use of directing groups, specifically a quinolinamide directing group, in a nickel-catalyzed reaction. This method allows for the efficient synthesis of branched molecules and demonstrates a high level of selectivity. The authors provide experimental results and optimization of reaction conditions to support their findings. Additionally, the article discusses the broad functional-group tolerance of the reaction and its potential applications in pharmaceutical modifications and large-scale reactions. [Extracted from the article]