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MISP Is Overexpressed in Intestinal Metaplasia and Gastric Cancer.

MISP Is Overexpressed in Intestinal Metaplasia and Gastric Cancer.

Authors :
Vilarinho, Tomás
Pádua, Diana
Pereira, Bruno
Mesquita, Patrícia
Almeida, Raquel
Source :
Current Oncology. May2024, Vol. 31 Issue 5, p2769-2779. 11p.
Publication Year :
2024

Abstract

Gastric cancer is the fifth most common cancer and the fourth cause of global cancer mortality. The identification of new biomarkers and drug targets is crucial to allow the better prognosis and treatment of patients. The mitotic spindle positioning (MISP) protein has the function of correcting mitotic spindle positioning and centrosome clustering and has been implicated in the cytokinesis and migration of cancer cells. The goal of this work was to evaluate the expression and clinical relevance of MISP in gastric cancer. MISP expression was evaluated by immunohistochemistry in a single hospital series (n = 286) of gastric adenocarcinomas and compared with normal gastric mucosa and intestinal metaplasia, a preneoplastic lesion. MISP was detected on the membrane in 83% of the cases, being overexpressed in gastric cancer compared to normal gastric mucosa (n = 10). Its expression was negatively associated with diffuse and poorly cohesive types. On the other hand, it was strongly expressed in intestinal metaplasia where it was associated with MUC2 and CDX2 expression. Furthermore, when we silenced MISP in vitro, a significant decrease in the viability of gastric carcinoma cells was observed. In conclusion, MISP is overexpressed in gastric cancer, being associated with an intestinal phenotype in gastric carcinogenesis and having a role in cellular proliferation. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
11980052
Volume :
31
Issue :
5
Database :
Academic Search Index
Journal :
Current Oncology
Publication Type :
Academic Journal
Accession number :
177496589
Full Text :
https://doi.org/10.3390/curroncol31050210