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SARS-CoV-2 and Influenza Co-Infection: Fair Competition or Sinister Combination?
- Source :
-
Viruses (1999-4915) . May2024, Vol. 16 Issue 5, p793. 11p. - Publication Year :
- 2024
-
Abstract
- The COVID-19 pandemic remains a serious public health problem globally. During winter influenza seasons, more aggressive SARS-CoV-2 infections and fatalities have been documented, indicating that influenza co-infections may significantly impact the disease outcome of COVID-19. Both influenza and SARS-CoV-2 viruses share many similarities in their transmission and their cellular tropism for replication in the human respiratory tract. However, the complex intricacies and multi-faceted dynamics of how the two pathogens interact to ensure their survival in the same lung microenvironment are still unclear. In addition, clinical studies on influenza co-infections in COVID-19 patients do not provide conclusive evidence of how influenza co-infection mechanistically modifies disease outcomes of COVID-19. This review discusses various viral as well as host factors that potentially influence the survival or synergism of these two respiratory pathogens in the infected lung microenvironment. [ABSTRACT FROM AUTHOR]
- Subjects :
- *INFLUENZA
*SARS-CoV-2
*MIXED infections
*COVID-19
*INFLUENZA viruses
Subjects
Details
- Language :
- English
- ISSN :
- 19994915
- Volume :
- 16
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Viruses (1999-4915)
- Publication Type :
- Academic Journal
- Accession number :
- 177496256
- Full Text :
- https://doi.org/10.3390/v16050793