Comment on Manole et al. Primary Pericardial Synovial Sarcoma: A Case Report and Literature Review. Diagnostics 2022, 12 , 158.

This document is a comment on a case report and literature review titled "Primary Pericardial Synovial Sarcoma" published in the journal Diagnostics. The authors discuss the diagnosis and imaging of synovial sarcoma (SS), a rare type of spindle cell sarcoma. They highlight the importance of pathology and imaging for precise diagnosis, as well as the limitations of fluorescence in situ hybridization (FISH) in confirming the diagnosis. The authors also introduce other diagnostic tools, such as immunohistochemistry (IHC) using SS18-SSX and SSX antibodies, and molecular confirmation using methods like RNA sequencing and fragment analysis. They emphasize the need for a variety of diagnostic approaches in cases of rare cancers and sarcomas. [Extracted from the article]