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Palmitic Acid Exerts Anti-Tumorigenic Activities by Modulating Cellular Stress and Lipid Droplet Formation in Endometrial Cancer.

Authors :
Zhao, Ziyi
Wang, Jiandong
Kong, Weimin
Newton, Meredith A.
Burkett, Wesley C.
Sun, Wenchuan
Buckingham, Lindsey
O'Donnell, Jillian
Suo, Hongyan
Deng, Boer
Shen, Xiaochang
Zhang, Xin
Hao, Tianran
Zhou, Chunxiao
Bae-Jump, Victoria L.
Source :
Biomolecules (2218-273X). May2024, Vol. 14 Issue 5, p601. 24p.
Publication Year :
2024

Abstract

Epidemiological and clinical evidence have extensively documented the role of obesity in the development of endometrial cancer. However, the effect of fatty acids on cell growth in endometrial cancer has not been widely studied. Here, we reported that palmitic acid significantly inhibited cell proliferation of endometrial cancer cells and primary cultures of endometrial cancer and reduced tumor growth in a transgenic mouse model of endometrial cancer, in parallel with increased cellular stress and apoptosis and decreased cellular adhesion and invasion. Inhibition of cellular stress by N-acetyl-L-cysteine effectively reversed the effects of palmitic acid on cell proliferation, apoptosis, and invasive capacity in endometrial cancer cells. Palmitic acid increased the intracellular formation of lipid droplets in a time- and dose-dependent manner. Depletion of lipid droplets by blocking DGAT1 and DGAT2 effectively increased the ability of palmitic acid to inhibit cell proliferation and induce cleaved caspase 3 activity. Collectively, this study provides new insight into the effect of palmitic acid on cell proliferation and invasion and the formation of lipid droplets that may have potential clinical relevance in the treatment of obesity-driven endometrial cancer. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
2218273X
Volume :
14
Issue :
5
Database :
Academic Search Index
Journal :
Biomolecules (2218-273X)
Publication Type :
Academic Journal
Accession number :
177493044
Full Text :
https://doi.org/10.3390/biom14050601