Solid-predominant ground-glass opacity has a higher recurrence rate.

Background: Although it is generally considered that ground-glass opacity (GGO) is less invasive and sublobar resection is adopted, recurrence still occurs in these patients. The risk factors that affect GGO recurrence need to be re-evaluated. Materials and Methods: We collect retrospectively the data of GGO patients and study the risk factors of tumor recurrence. Patients with T1N0M0 lung adenocarcinoma who underwent lung resection from 2011 to 2016 were enrolled in the study. The collected variables included GGO size, solid part size, consolidation/tumor ratio (CTR), clinical T stage, surgical procedure, and pathology report, from which the risk factors affecting tumor recurrence were analyzed. Results: A total of 28 recurred in 694 patients. Risk factors include age, tumor size, solid part size, CTR ≥50%, and surgical procedures. After multivariate analysis, the only risk factor was CTR ≥50% that will affect tumor recurrence (hazard ratio: 6.789, P < 0.001). Conclusion: CTR ≥50% is a risk factor affecting GGO recurrence. Clinicians should be more careful with such tumors. [ABSTRACT FROM AUTHOR]