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Blood compatibility of poly(propylene glycol diester) and its water structure observed by differential scanning calorimetry and 2H-nuclear magnetic resonance spectroscopy.

Authors :
Mochizuki, Akira
Udagawa, Ayaka
Miwa, Yuko
Oda, Yoshiki
Yoneyama, Konatsu
Okuda, Chihiro
Source :
Journal of Biomaterials Science -- Polymer Edition. Jun2024, Vol. 35 Issue 8, p1258-1272. 15p.
Publication Year :
2024

Abstract

Recently, we applied solution 2H-nuclear magnetic resonance spectroscopy (2H NMR) to analyze the water (deuterium oxide, D2O) structure in several biopolymers at ambient temperature. We established that polymers with good blood compatibility (i.e. poly(2-methoxyethyl acrylate) (PMEA)) have water observed at high magnetic fields (upfield) compared with bulk water. Polymers containing poly(propylene glycol) (PPG) or poly(propylene oxide) (PPO) exhibit good compatibility; however, the reason for this remains unclear. In addition, reports on the blood compatibility of PPO/PPG are limited. Therefore, PPG diester (PPGest) was prepared as a model polymer, and its blood compatibility and water structure were investigated. PPGest exhibited excellent blood compatibility. The water in PPGest was observed upfield by 2H NMR, and it was defined as non-freezing water via differential scanning calorimetry. Based on these observations, the relationship between the blood compatibility and water structure of PPGest is discussed by comparing with those of PMEA, and the reason for the good performance of PPG/PPO-based polymers is discussed. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
09205063
Volume :
35
Issue :
8
Database :
Academic Search Index
Journal :
Journal of Biomaterials Science -- Polymer Edition
Publication Type :
Academic Journal
Accession number :
177396216
Full Text :
https://doi.org/10.1080/09205063.2024.2324505