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Isoflavones isolated from the fruits of Ficus altissima and their anti-proliferative activities.
- Source :
-
Fitoterapia . Jun2024, Vol. 175, pN.PAG-N.PAG. 1p. - Publication Year :
- 2024
-
Abstract
- Ficus altissima , also known as lofty fig, is a monoecious plant from the Moraceae family commonly found in southern China. In this study, we isolated and identified one new isoflavone (1), three new hydroxycoumaronochromones (2a , 2b and 3a) and 12 known compounds from the fruits of F. altissima. Their chemical structures were determined using spectroscopic analysis methods. We also tested all the isolated compounds for their anti-proliferative activities against eight human tumour cell lines (A-549, AGS, K562, K562/ADR, HepG2, HeLa, SPC-A-1 and CNE2) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay. Our experiments showed that compound 6 exhibited obvious anti-proliferative activity against the K562 cell line with an IC 50 value of 1.55 μM. Additionally, compounds 8 and 9 showed significant anti-proliferative activities against the AGS and K562 cell lines, respectively. Moreover, compound 6 induced apoptosis in K562 cells through the caspase family signalling pathway. [Display omitted] • Four new isoflavones were isolated from the fruits of Ficus altissima. • Compound 6 showed obvious anti-proliferative effect against K562 cell line. • Compounds 8 and 9 showed anti-proliferative effects against AGS and K562 cells. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 0367326X
- Volume :
- 175
- Database :
- Academic Search Index
- Journal :
- Fitoterapia
- Publication Type :
- Academic Journal
- Accession number :
- 177391234
- Full Text :
- https://doi.org/10.1016/j.fitote.2024.105966