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The Emerging Role of Vitamin D in Neurological Health and Disease.
- Source :
-
Global Journal of Medical Pharmaceutical & Biomedical Update . 2023, Vol. 18, p1-7. 7p. - Publication Year :
- 2023
-
Abstract
- Vitamin D has come up as a pluripotent biochemical modulator of several systemic functions including its wellestablished musculoskeletal effects functioning as well as other key roles in nervous, cardiac, immune, vascular, and endocrinological systems. It undergoes metabolic activation in the skin, liver, and kidneys to exert its systemic actions primarily through Vitamin D receptor-mediated gene expression. In recent times, the involvement of Vitamin D has been documented in the regulation of neurotrophins, neural differentiation, and maturation, and the synthesis of neuromodulators including acetylcholine, dopamine, and gamma-aminobutyric acid. Clinical studies have also highlighted the involvement of Vitamin D in neurological disorders, thereby underscoring its potential in the clinical management of such disorders. Further, research is required to determine the multipronged roles of Vitamin D and its molecular pathways in neurophysiology for the potential prevention and treatment of neurological dysfunction. [ABSTRACT FROM AUTHOR]
- Subjects :
- *CEREBROVASCULAR disease risk factors
*ALZHEIMER'S disease risk factors
*CENTRAL nervous system physiology
*PERIPHERAL nervous system physiology
*AUTONOMIC nervous system physiology
*VITAMIN D metabolism
*COGNITION disorder risk factors
*MULTIPLE sclerosis risk factors
*VITAMIN D deficiency
*RISK assessment
*NEUROPHYSIOLOGY
*NEURAL development
*BIOCHEMISTRY
*PARKINSON'S disease
*NEUROLOGICAL disorders
*GENE expression
*CHOLECALCIFEROL
*AMYOTROPHIC lateral sclerosis
*MOLECULAR structure
*DOPAMINE
*VITAMIN D
*BIOMARKERS
*NERVE growth factor
*ACETYLCHOLINE
*GABA
*DIET
*COGNITION
*DISEASE risk factors
*DISEASE complications
Subjects
Details
- Language :
- English
- ISSN :
- 27658910
- Volume :
- 18
- Database :
- Academic Search Index
- Journal :
- Global Journal of Medical Pharmaceutical & Biomedical Update
- Publication Type :
- Academic Journal
- Accession number :
- 177382771
- Full Text :
- https://doi.org/10.25259/GJMPBU_31_2023