Clarifying the role of D1 receptor signalling in Alzheimer's‐related epilepsy commentary on Szabo et al. (2024).

This article discusses the role of D1 receptor signaling in Alzheimer's-related epilepsy. The authors explore the hypothesis that dopaminergic pathways, specifically those involving D1-like DA receptors, contribute to an increase in epileptic events. They conducted experiments using a D1-receptor antagonist in AD mouse models and found that it did not significantly alter the frequency of epileptic activity. The authors suggest that further analysis is needed to fully understand the role of D1 receptor signaling in epilepsy and that therapeutic interventions should focus on addressing the root causes of D1 receptor overexpression. [Extracted from the article]