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Cp*Ir‐Catalyzed C−H Arylation of 2‐Pyridones and 1‐Isoquinolinones with Arylsilanes.
- Source :
-
Advanced Synthesis & Catalysis . 5/21/2024, Vol. 366 Issue 9, p2109-2114. 6p. - Publication Year :
- 2024
-
Abstract
- A Cp*Ir‐catalyzed C−H arylation of 1‐isoquinolinone and 2‐pyridones with N‐2‐pyridyl as a directing group to afford 6‐phenylpyridin‐2(1H)‐ones and 3‐phenylisoquinolin‐1(2H)‐ones by using arylsilanes is described in this paper. This method tolerates a series of functional groups, such as halide, trifluoromethyl, C=C double bond and offers a synthetic approach to the core structure of protoberberine alkaloids. Several experiments on mechanism studies were conducted to reveal the possible process of this Cp*Ir‐catalytic cycle. [ABSTRACT FROM AUTHOR]
- Subjects :
- *ARYLATION
*DOUBLE bonds
*PROTOBERBERINE
*ALKALOIDS
*FUNCTIONAL groups
Subjects
Details
- Language :
- English
- ISSN :
- 16154150
- Volume :
- 366
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Advanced Synthesis & Catalysis
- Publication Type :
- Academic Journal
- Accession number :
- 177377952
- Full Text :
- https://doi.org/10.1002/adsc.202400029