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Surveying biomedical relation extraction: a critical examination of current datasets and the proposal of a new resource.

Authors :
Huang, Ming-Siang
Han, Jen-Chieh
Lin, Pei-Yen
You, Yu-Ting
Tsai, Richard Tzong-Han
Hsu, Wen-Lian
Source :
Briefings in Bioinformatics. May2024, Vol. 25 Issue 3, p1-17. 17p.
Publication Year :
2024

Abstract

Natural language processing (NLP) has become an essential technique in various fields, offering a wide range of possibilities for analyzing data and developing diverse NLP tasks. In the biomedical domain, understanding the complex relationships between compounds and proteins is critical, especially in the context of signal transduction and biochemical pathways. Among these relationships, protein–protein interactions (PPIs) are of particular interest, given their potential to trigger a variety of biological reactions. To improve the ability to predict PPI events, we propose the protein event detection dataset (PEDD), which comprises 6823 abstracts, 39 488 sentences and 182 937 gene pairs. Our PEDD dataset has been utilized in the AI CUP Biomedical Paper Analysis competition, where systems are challenged to predict 12 different relation types. In this paper, we review the state-of-the-art relation extraction research and provide an overview of the PEDD's compilation process. Furthermore, we present the results of the PPI extraction competition and evaluate several language models' performances on the PEDD. This paper's outcomes will provide a valuable roadmap for future studies on protein event detection in NLP. By addressing this critical challenge, we hope to enable breakthroughs in drug discovery and enhance our understanding of the molecular mechanisms underlying various diseases. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
14675463
Volume :
25
Issue :
3
Database :
Academic Search Index
Journal :
Briefings in Bioinformatics
Publication Type :
Academic Journal
Accession number :
177375758
Full Text :
https://doi.org/10.1093/bib/bbae132