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ITAM‐based receptors in natural killer cells.
- Source :
-
Immunological Reviews . May2024, Vol. 323 Issue 1, p40-53. 14p. - Publication Year :
- 2024
-
Abstract
- Summary: The ability of cells of the immune system to acquire features such as increased longevity and enhanced secondary responses was long thought to be restricted to cells of the adaptive immune system. Natural killer (NK) cells have challenged this notion by demonstrating that they can also gain adaptive features. This has been observed in both humans and mice during infection with cytomegalovirus (CMV). The generation of adaptive NK cells requires antigen‐specific recognition of virally infected cells through stimulatory NK receptors. These receptors lack the ability to signal on their own and rather rely on adaptor molecules that contain ITAMs for driving signals. Here, we highlight our understanding of how these receptors influence the production of adaptive NK cells and propose areas in the field that merit further investigation. [ABSTRACT FROM AUTHOR]
- Subjects :
- *KILLER cells
*KILLER cell receptors
*CYTOMEGALOVIRUS diseases
*IMMUNE system
Subjects
Details
- Language :
- English
- ISSN :
- 01052896
- Volume :
- 323
- Issue :
- 1
- Database :
- Academic Search Index
- Journal :
- Immunological Reviews
- Publication Type :
- Academic Journal
- Accession number :
- 177322091
- Full Text :
- https://doi.org/10.1111/imr.13313