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Electrocardiographic, biochemical, and scintigraphic evidence for the cardioprotective effect of paricalcitol and vitamin D³ on doxorubicin-induced acute cardiotoxicity in rats.
- Source :
-
Bratislava Medical Journal / Bratislavské Lekárske Listy . 2024, Vol. 125 Issue 5, p281-288. 8p. - Publication Year :
- 2024
-
Abstract
- AIM: We aimed to investigate the possible cardioprotective effects of paricalcitol (PR), its vitamin D receptor agonist, and vitamin D³3 (VIT-D3) on an experimental model of doxorubicin (DX) cardiotoxicity by 99mTc-PYP scintigraphy, electrocardiographic (ECG) and biochemical methods. METHOD: Forty-two male Wistar/Albino rats (250-300 g; aged 10-12 weeks) were randomly separated into six groups, namely into control (CN), doxorubicin (DX), paricalcitol (PR), vitamin D³ (VIT-D³), paricalcitol + doxorubicin (PR+DX), and vitamin D³ + doxorubicin (VIT-D³+DX) groups. Cardiotoxicity was induced by three doses of DX (18 mg/kg, i.p.) at 24-hour intervals on days 18, 19 and 20. PR (0.5 ug/ kg, i.p) and VIT-D³ (5,000 IU/kg, i.p) were injected for 20 days before and after the application of DX (18 mg/kg, i.p.). On day 21 of the experiment, biochemical parameters [tumor necrosis factor TNF-alpha (TNF-α); interleukin-6 (IL-6), nitric oxide (NO), and cardiac troponin T (cTnT)], as well as ECG and scintigraphic (99mTc-PYP) features were assessed. RESULTS: Compared to CN, DX significantly raised TNF-α, IL-6, and NO in heart tissue, cTnT in serum, 99mTc-PYP uptake in the myocardium, and ECG parameters, specifically QRS complex duration, QT interval duration, and ST-segment amplitude, while also reducing heart rate (p<0.001). Pretreatment with PR and VIT-D³ mitigated these abnormalities produced by DX in the heart (p<0.001). CONCLUSION: Results show that vitamin D receptor agonist paricalcitol and vitamin D protect against DX-induced cardiotoxicity through anti-inflammatory and antioxidant effects [ABSTRACT FROM AUTHOR]
- Subjects :
- *CARDIOTOXICITY
*VITAMIN D receptors
*TUMOR necrosis factors
*VITAMINS
*RATS
Subjects
Details
- Language :
- English
- ISSN :
- 00069248
- Volume :
- 125
- Issue :
- 5
- Database :
- Academic Search Index
- Journal :
- Bratislava Medical Journal / Bratislavské Lekárske Listy
- Publication Type :
- Academic Journal
- Accession number :
- 177313081
- Full Text :
- https://doi.org/10.4149/BLL_2024_42