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Photocatalytic organosulfur reagent-promoted selective mono-(deutero)hydrodechlorination.
- Source :
-
Green Chemistry . 5/7/2024, Vol. 26 Issue 9, p5167-5172. 6p. - Publication Year :
- 2024
-
Abstract
- Selective partial C--Cl bond reduction represents an important strategy for the construction of valuable chlorine-containing skeletons. Herein, we report an efficient and straightforward mono-(deutero)hydrodechlorination strategy of various trichloroacetyl esters and amides for the incorporation of gem-dichloromethyl moieties. The proposed mechanism involves key electron donor--acceptor (EDA) complexes formed between catalytic cyclohexanethiol (CySH) and substrates, which undergo single-electron transfer (SET) processes under blue light irradiation to provide the gem-dichloro radical anion and CyS•. A gram-scale reaction and late-stage modification of bioactive molecules further demonstrate the potential utility of this methodology. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 14639262
- Volume :
- 26
- Issue :
- 9
- Database :
- Academic Search Index
- Journal :
- Green Chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 177263845
- Full Text :
- https://doi.org/10.1039/d4gc01173b