Secofumitremorgins C and D, a pair of atropisomers from saltern-derived fungus <italic>Aspergillus fumigatus</italic> GXIMD00544.

AbstractA pair of atropisomers secofumitremorgins C (<bold>1a</bold>) and D (<bold>1b</bold>), together with fifteen known alkaloids (<bold>2-16</bold>), were isolated from a saltern-derived fungus <italic>Aspergillus fumigatus</italic> GXIMD00544. The structures of atropisomers <bold>1a</bold> and <bold>1b</bold> were elucidated by the detailed spectroscopic data, chemical reaction and quantum chemical calculations. Compounds <bold>1</bold> and <bold>8</bold> displayed antifungal spore germination effects against plant pathogenic fungus associated with sugarcane <italic>Fusarium</italic> sp. with inhibitory rates of 53% and 77% at the concentration of 100 µM, repectively. Atropisomers <bold>1</bold> also exhibited antifouling potential against <italic>Balanus amphitrite</italic> larval settlement with an inhibitory rate of 96% at the concentration of 100 µM. [ABSTRACT FROM AUTHOR]