Persistent and symptomatic periodic breathing beyond the neonatal period in full-term infants: A case series.

• Persistent and symptomatic periodic breathing (PB) was observed after 1 month of life in infants born at term. • Persistent and symptomatic PB was observed with the presence of obstructive sleep apnea syndrome (OSAS) and/or central apnea syndrome (CAS), along with gastroesophageal reflux. • Persistent and symptomatic PB improved after temporary treatment with oxygen or ventilatory support. • Persistent and symptomatic PB decreased with age and disappeared during the first year of life. • Polysomnography recording and its interpretation by professionals trained in pediatric sleep is important for distinguishing between PB, OSAS, and CAS and for proposing an adapted treatment. Periodic breathing (PB) is considered physiological in the neonatal period and usually disappears in the first months of life. There are few data available on persistent PB after the neonatal period. The objective of this study was to characterize infants born at term with persistent PB after the age of 1 month through polysomnography (PSG) performed during symptoms. This retrospective case series included infants born at term between 2012 and 2021, without an underlying disease, who presented with symptoms of persistent PB during a PSG. Persistent PB was defined as more than 1 % of total sleep time (TST) of PB after 1 month of life, and PB was defined as a succession of at least three episodes of central apnea lasting more than 3 s and separated by less than 20 s of normal breathing. A total of 10 infants born at term were included. They underwent PSG for brief resolved unexplained events, desaturation, pauses in breathing, cyanosis, and/or signs of respiratory distress. The percentage of TST spent with PB was 18.1 % before 3 months of age (n = 7), and 4.7 % between 3 and 6 months of age (n = 10). During the first PSG, ≥3 % of desaturation events were observed in 77–100 % of the PB episodes. At the first PSG, nine of the 10 infants had an obstructive apnea–hypopnea index of >10/h and five of 10 infants had a central apnea index of >5/h. Gastroesophageal reflux (GER) was suspected in eight infants. All infants showed improvement in the initial symptoms during the first year of life. This study presents cases of persistent and symptomatic PB after 1 month of life in infants born at term. The interesting finding was the presence of obstructive sleep apnea syndrome and/or central apnea syndrome in the majority of children, along with GER. [ABSTRACT FROM AUTHOR]