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Chitosan‐coated nanoparticles in innovative cancer bio‐medicine.

Authors :
Rezaei, Niloufar
Zarkesh, Ibrahim
Fotouhi, Alireza
Alikhani, Hani Keshavarz
Hassan, Moustapha
Vosough, Massoud
Source :
Drug Development Research. May2024, Vol. 85 Issue 3, p1-13. 13p.
Publication Year :
2024

Abstract

In the recent decade, nanoparticles (NPs) have had enormous implications in cancer biomedicine, including research, diagnosis, and therapy. However, their broad application still faces obstacles due to some practical limitations and requires further development. Recently, there has been more interest in the coated class of nanoparticles to address those challenges. Chitosan‐coated NPs are simple to produce, biodegradable, biocompatible, exhibit antibacterial activity, and have less cytotoxicity. This study provides an updated and comprehensive overview of the application of chitosan‐coated NPs as a promising class of NPs in cancer biomedicine. Additionally, we discussed chitosan‐coated lipid, metal, and polymer‐based nanoparticles in biomedical applications. Furthermore, different coating methods and production/characterization procedures were reviewed. Moreover, the biological and physicochemical advantages of chitosan‐coated NPs, including facilitated controlled release, greater physicochemical stability, improved cell/tissue interaction, and enhanced bioavailability of medications, were highlighted. Finally, the prospects of chitosan‐coated NPs in cancer biomedicine were discussed. [ABSTRACT FROM AUTHOR]

Details

Language :
English
ISSN :
02724391
Volume :
85
Issue :
3
Database :
Academic Search Index
Journal :
Drug Development Research
Publication Type :
Academic Journal
Accession number :
177244105
Full Text :
https://doi.org/10.1002/ddr.22189