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Comparison of Clinicopathological Features of Pleomorphic and Invasive Lobular Breast Carcinomas.
- Source :
-
American Surgeon . Jun2024, Vol. 90 Issue 6, p1383-1389. 7p. - Publication Year :
- 2024
-
Abstract
- Purpose: Accounting for about 15% of invasive lobular carcinomas and 1% of breast carcinomas, pleomorphic lobular carcinoma is known to be a rare histological subtype of invasive lobular carcinoma. Yet, it is more aggressive and produces a worse prognosis than other breast cancers. Ultimately, the present study compares the clinicopathological features of pleomorphic and invasive lobular breast carcinomas. Methods: In the study, we retrospectively evaluated the data of 262 patients with histological subtypes of classical and pleomorphic lobular cancers having been recruited for surgical operations. After resorting to Kolmogorov-Smirnov and Shapiro-Wilk tests to check the normality of distribution, the categorical and continuous variables were compared between the groups using the chi-square test and independent samples t test, respectively. In all analyses, we considered a P -value of <.05 to be statistically significant. Results: Our findings revealed that the groups with lobular and pleomorphic groups significantly differed by Ki-67 value, estrogen receptor negativity, grade, multicentricity, multifocality, surgical margin positivity, completion mastectomy, and metachronous contralateral tumor (P <.05). Conclusion: We discovered that pleomorphic type was associated with higher grades, estrogen receptor negativity, and Ki-67 expression. The incidence of metachronous breast cancer was high in the pleomorphic group, which may be a noteworthy finding to be considered in follow-ups. In addition, the high rates of multicentricity and multifocality of tumors in the pleomorphic group may be associated with increased surgical margin positivity and a higher likelihood of mastectomy. In a nutshell, our findings may guide patients and surgeons regarding the type of intervention and reconstruction options to be adopted in prospective surgeries. [ABSTRACT FROM AUTHOR]
Details
- Language :
- English
- ISSN :
- 00031348
- Volume :
- 90
- Issue :
- 6
- Database :
- Academic Search Index
- Journal :
- American Surgeon
- Publication Type :
- Academic Journal
- Accession number :
- 177241975
- Full Text :
- https://doi.org/10.1177/00031348241241612