RETRACTED: Up‐regulation of p21WAF1/CIP1 by miRNAs and its implications in bladder cancer cells.

We have previously reported that synthetic dsRNA can activate p21 expression by targeting the p21 promoter, thereby suppressing the proliferation of human bladder cancer cells. As complementarity between dsRNA and its target sequences is necessary for RNA activation, miRNAs may also trigger p21 expression through the same mechanism. Here, the expression levels of three miRNAs (miR‐370, miR‐1180 and miR‐1236) decreased in bladder cancer tissues compared to healthy controls and the levels of these mRNAs positively correlated with p21 mRNA levels. The three miRNAs induced nuclear p21 expression through p21‐promoter binding. Overexpression of the three miRNAs inhibited the proliferation of bladder cancer cells mainly by regulating p21. Therefore, these miRNAs could be candidates for anti‐cancer drugs.miR‐370, miR‐1180 and miR‐1236 were lower expression in bladder cancer. miRNAs levels positively correlate p21 mRNA levels in bladder cancer tissues. miRNAs induce nuclear p21 expression in human bladder cancer cells. miRNAs upregulate p21 by directly targeting its promoter. miRNAs inhibit bladder cancer cells by upregulating p21. [ABSTRACT FROM AUTHOR]