To investigate the relationship between levels of 25-hydroxy vitamin D and neonatal hyperbilirubinemia in healthy term newborns.

Aim: To investigate the relationship between levels of 25-hydroxy vitamin D and neonatal hyperbilirubinemia in healthy-term newborns. Material and methods: The research included 200 babies, 100 classifieds as cases, and 100 as controls. Subjects were selected as cases or controls based on their serum bilirubin levels. The newborns in the cases group had bilirubin levels within the normal physiological range and did not need any treatment. In contrast, the newborns in the control group had serum bilirubin levels that fell within the range requiring intervention, such as phototherapy, exchange transfusion, or other treatment types, as the American Academy of Pediatrics recommended. The research characterized the state of vitamin D levels as follows: Insufficiency: <20 ng/ml. The range is suboptimal, with a 5-10 ng/ml value. The optimal amount of vitamin D is often between 30 to 50 ng/ml. Results: The mean serum bilirubin level in the cases was 18.47 mg/dl, with a standard deviation of 2.45. This was significantly higher than the mean serum bilirubin level in the control group, which was 8.45 mg/dl with a standard deviation of 0.36. The vitamin D levels in the mothers of the cases and controls were 22.67ng/ml and 26.82 ng/ml, respectively. The standard deviations for these levels were 3.89 and 2.95, respectively. The newborns in the cases had a vitamin D level of 12.56 ng/ml with a standard deviation of 2.11. In contrast, the newborns in the control group had a vitamin D level of 21.35 ng/ml with a standard deviation of 2.17. Our research found that the average vitamin D levels in the mothers of newborns were 22.67 ng/ml for cases and 26.82 ng/ml for controls. The mean difference between the two groups was -6.59 ng/ml. However, the p-value of 0.07 indicates this difference is not statistically significant. Nevertheless, an essential statistical distinction was seen in the vitamin D levels between the cases and controls (P value 0.01). The patients had a mean vitamin D level of 12.56 ng/ml, while the controls had a mean vitamin D level of 21.35 ng/ml, resulting in a mean difference of -8.79. Conclusion: We found that newborns who experienced jaundice had a low vitamin D level that fell beyond the normal range. Furthermore, their blood bilirubin and vitamin D levels had a strong negative association. [ABSTRACT FROM AUTHOR]