Organocatalytic, Chemoselective, and Stereospecific House–Meinwald Rearrangement of Trisubstituted Epoxides.

This article presents a new method for synthesizing α-quaternary carbaldehydes through the chemoselective House-Meinwald rearrangement of trisubstituted epoxides. The authors used Brønsted acids as catalysts and identified optimal reaction conditions. The method allows for the synthesis of various carbaldehydes and has been validated for stereospecific reactions. The authors suggest that this method could be useful in the total synthesis of natural products. [Extracted from the article]